Rheum Palmatum syrup and NAFLD

The effect of Rheum Palmatum syrup (traditional medicine product) with diet and exercise in comparison with diet and exercise alone on liver enzymes in patients with non-alcoholic fatty liver (NAFLD)

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211019052813N1

Enrollment

Registered

2021-11-21

Start date

2021-11-22

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver disease. K76.0Fatty (change of) liver, not elsewhere classified Nonalcoholic fatty liver disease (NAFLD)

Interventions

Intervention 1: Intervention group: Receiving Rheum Palmatum syrup along with receiving exercise instructions and diet modification training. Intervention 2: Control group: Receiving exercise instruct

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Age between 18 and 60 years Fatty liver disease based on high liver enzymes

Exclusion criteria

Exclusion criteria: Type 1 and type 2 diabetes (requires medication) Positive serology of viral hepatitis B and C (anti-HCV or HBsAg positive) Liver and kidney disease Blood pressure-requiring medication (BP> 85/85 mmhg) Liver cirrhosis Pregnancy and lactation Hyperlipidemia (requires medication TG> 150mg / dl) Wilson and hemochromatosis Autoimmune hepatitis Taking drugs such as valproate, amiodarone, methotrexate, tamoxifen, corticosteroids Hypothyroidism (requires medication) Active malignancy in the body

Design outcomes

Primary

Measure	Time frame
Liver enzymes (ALT, AST). Timepoint: Baseline, after one month and after three months from the beginning of the study. Method of measurement: Measurement of serum levels of serum enzymes quantitatively.;Body mass index. Timepoint: Baseline, after one month and after three months from the beginning of the study. Method of measurement: weight in kilograms divided by height in meters squared.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Mohebbi

Tehran University of Medical Sciences

dr.m_mohebi@yahoo.com+98 17 3358 7989

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026