Knee Osteoarthritis. Osteoarthritis of knee
Conditions
Interventions
Intervention 1: Intervention group 1: The Group which treated by injection of platelet-rich plasma extracted single centrifuged. One week before the injection, an MRI of the patient's affected knee is
Sponsors
Iran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: Patients with grade 2 or 3 primary osteoarthritis of the knee as determined by the Kellgren and Lawrence criteria (knee pain, morning stiffness less than 30 minutes, crepitus on movement and radiological signs of osteoarthritis include joint space loss, subchondral bone sclerosis and the formation of osteophytes in knee) Patients aged 50-75 years Patients who have persistent knee pain for at least six months and with an intensity of at least 4 according to the VAS scale in activities such as going up and down stairs, sitting for long periods and squatting Patients who are able to walk independently for at least 30 meters Patients with a body mass index equal to or less than 35 The patient has full consent to participate in the study The patient has a balanced mental state
Exclusion criteria
Exclusion criteria: The patient has any contraindications for MRI, including aneurysm clips, pacemakers, metal devices in the body, and claustrophobia The patient has a history of intra-articular injection in the knee during the last six months The patient has neuromuscular diseases The patient has a history of acute traumatic injury to other ligaments and structures of the knee joint with the approval of a specialist The patient has a history of surgery or previous injury in the knee and other lower limb joints over the last year The patient has bone implants The patient has a new fracture in the lower extremities during the last year The patient has malignant tumors The patient has participated in exercise therapy and physiotherapy programs during the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Knee MRI Changes Based on MRI Osteoarthritis Knee Score (MOAKS). Timepoint: Before the intervention and six months after the intervention. Method of measurement: Using the PACS system.;Knee function with WOMAC(Western Ontario and McMaster Universities Osteoarthritis Index) scale. Timepoint: Before the intervention and one month and three months after the intervention. Method of measurement: Western Ontario and McMaster Universities Osteoarthritis Index questionnaire.;Feeling knee pain by Visual Analogue Scale (VAS). Timepoint: Before the intervention and one month and three months after the intervention. Method of measurement: Visual Analogue Scale (VAS).;Knee range of motion. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Goniometry.;Timed Up & Go test: The ability of a person to get up from a chair over a distance of 3 meters. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Stopwatch (seconds).;Six Minute Walk test: The person's ability to walk for 6 minutes. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: Distance measurement (meter).;Stair climbing test: The ability of a person to climb stairs to reach the stage of pain or fatigue. Timepoint: Before the intervention, one month and three months after the intervention. Method of measurement: The number of steps taken. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMostafa Ghadamzadeh
Iran University of Medical Sciences
Outcome results
None listed