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Comparison of vaginal estradiol in cervical ripening with misoprostol

Comparison of vaginal misoprostol with and without vaginal estrogen in cervical ripening before operative hysteroscopy in postmenopausal women

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211013052756N1
Enrollment
102
Registered
2021-11-05
Start date
2019-12-22
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Menopause. Menopausal and other perimenopausal disorders

Interventions

Intervention 1: Intervention group: Patients in the intervention group were treated with one third of 4 gr applicator of vaginal cream 0.625mg estrogen conjugate (each 1gr contains 0.625 mg conjugate

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female

Inclusion criteria

Inclusion criteria: Postmenopausal women (at least more than 1 year after the last menstrual cycle) Candidates for hysteroscopy Patients must have a normal mammogram and Pap smear within the last 2 years

Exclusion criteria

Exclusion criteria: Recent or current pelvic infection History of cervical conization Previous surgery on the cervix hypersensitivity to prostaglandins History of venous thrombosis Cardiovascular disease Cervical or breast malignancies Mullerian anomaly Cervical anomalies

Design outcomes

Primary

MeasureTime frame
Hegar cervical dilator during hysteroscopy. Timepoint: One during hysteroscopy. Method of measurement: Observation.

Secondary

MeasureTime frame
Cervical softness and stenosis. Timepoint: One during hysteroscopy. Method of measurement: Observation.;Pain. Timepoint: One 6 hours after hysteroscopy. Method of measurement: Visual analogue scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Kiani

Iran University of Medical Sciences

dr.m.kiani87@gmail.com+98 21 2286 4111

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026