The effect of adding intravenous ketamine to Midazolam in reducing the need for analgesia after spinal anesthesia in elective cesarean section

Investigating the effect of adding intravenous ketamine to Midazolam in reducing the need for analgesia after spinal anesthesia in elective cesarean section

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211013052753N1

Enrollment

Registered

2021-11-14

Start date

2021-11-16

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fetal cesarean section. Delivery by caesarean section, unspecified

Interventions

Intervention 1: Intervention group: In this group, patients are injected with 0.5 mg/kg ketamine and 0.02 mg/kg midazolam in a 2ml syringe during cesarean section after umbilical cord clamping. Interv

Eligibility

Sex/Gender

Female

Inclusion criteria

Inclusion criteria: Women over the age of 18 who have elective cesarean section with ASA I (American Anesthesiology Association)

Exclusion criteria

Exclusion criteria: History of trauma to head, addiction and use of psychiatric medication Hallucinations, delusions and hypertension Intracranial hemorrhage History of ketamine allergy

Design outcomes

Primary

Measure	Time frame
Pain intensity. Timepoint: At 1,6,12 and 24 hours after labor. Method of measurement: The visual analog scale (VAS) for pain.;The amount of pain medication used. Timepoint: During the first day after the intervention. Method of measurement: Based on milligrams of Apotel and meperidine used.;Apgar score of the newborn. Timepoint: Minutes 1 and 4 after birth. Method of measurement: Examination.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaleheh Asghari

Mashhad University of Medical Sciences

AsghariSA@mums.ac.ir+98 51 3802 2406

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026