Comparison of chemotherapy before and after definitive chemotherapy-radiotherapy with definitive chemotherapy-radiotherapy alone in patients with advanced cervical cancer

Comparative of neoadjuvant chemotherapy fallowed by definitive chemo-radiotherapy and adjuvant chemotherapy versus definitive chemoradiotherapy alone in locally advanced cervical cancer

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211011052730N1

Enrollment

Registered

2024-01-02

Start date

2024-02-29

Completion date

Unknown

Last updated

2024-01-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cancer of cervix. Malignant neoplasm of endocervix

Interventions

Intervention 1: Intervention group: One group will undergo a neoadjuvant protocol along with concomitant chemoradiotherapy. Initially, patients will receive four cycles of weekly carboplatin AUC=2 and

Eligibility

Sex/Gender

Female

Age

20 Years to 80 Years

Inclusion criteria

Inclusion criteria: Patients with advanced cervical cancer (FIGO Ib3-II-III-IVA)

Exclusion criteria

Exclusion criteria: Previous treatment with neoadjuvant chemotherapy History of previous surgical treatment History of radiotherapy in the pelvis and abdomen

Design outcomes

Primary

Measure	Time frame
Disease free survival. Timepoint: One year and two year after intervention. Method of measurement: Physical exam and pelvic MRI.;Improved treatment response. Timepoint: One year and two year after intervention. Method of measurement: Physical exam and pelvic MRI.;Reduction of radiation therapy-related side effects. Timepoint: One year and two year after intervention. Method of measurement: History and Physical exam and pelvic MRI.	—

Measure

Time frame

Disease free survival. Timepoint: One year and two year after intervention. Method of measurement: Physical exam and pelvic MRI.;Improved treatment response. Timepoint: One year and two year after intervention. Method of measurement: Physical exam and pelvic MRI.;Reduction of radiation therapy-related side effects. Timepoint: One year and two year after intervention. Method of measurement: History and Physical exam and pelvic MRI.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahrzad Ebrahimi

Shahid Beheshti University of Medical Sciences

shahrzadebrahimi@sbmu.ac.ir+98 21 7343 3000

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026