Investigating the effect of midodrine in preventing hypotension

A clinical trial study to investigate the effect of oral midodrine in reducing the incidence of hypotension after spinal anesthesia in patients undergoing orthopedic surgery.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211011052726N4

Enrollment

Registered

2025-07-17

Start date

2025-07-23

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypotension after spinal anesthesia. Postprocedural hypotension

Interventions

Intervention 1: Intervention group: A Midodrine 5 mg tablet, manufactured by Cipla India, is given to the patient one hour before spinal anesthesia. Intervention 2: Control group: A placebo tablet of

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Inclusion criteria

Inclusion criteria: Ages between 18-50 years Patients who are candidates for orthopedic surgery under spinal anesthesia ASA (American Society of Anesthesiologists) class 1 and 2

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
Percentage of people who have a mean arterial pressure less than 80% of baseline within 45 minutes after spinal anesthesia. Timepoint: Blood pressure measurement at 15 minutes after drug administration (1 hour before spinal anesthesia) and after spinal anesthesia at every 2 minutes for 20 minutes and then every 5 minutes until the end of the surgery. Method of measurement: Dial and cuff sphygmomanometer.	—

Measure

Time frame

Percentage of people who have a mean arterial pressure less than 80% of baseline within 45 minutes after spinal anesthesia. Timepoint: Blood pressure measurement at 15 minutes after drug administration (1 hour before spinal anesthesia) and after spinal anesthesia at every 2 minutes for 20 minutes and then every 5 minutes until the end of the surgery. Method of measurement: Dial and cuff sphygmomanometer.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNafiseh Faghani Makrani

Mazandaran University of Medical Sciences

dr.nfaghani@gmail.com+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026