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Comparing the effectiveness of methadone with morphine in pain control

Comparing the effectiveness of methadone with morphine in pain control in patients after lumbar fusion surgery

Status
Active, not recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211011052726N3
Enrollment
100
Registered
2025-07-10
Start date
2025-06-04
Completion date
Unknown
Last updated
2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain intensity. Pain, unspecified

Interventions

Intervention 1: Intervention group 1: Methadone 0.2 mg/kg, made in Iran, Faran Shimi Company, intramuscularly for 24 hours, normal saline 0.1 mg/kg, made in Iran, Faran Shimi Company, intravenously fo

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: Age 18 to 70 years Patients with ASA (American Society of Anesthesiologists) class1 and 2 Patients who are candidates for elective lumbar fusion surgery Consent to participate in the study

Exclusion criteria

Exclusion criteria: History of chronic renal failure before surgery Liver disease (cirrhosis or liver failure) Lung disease requiring home oxygen therapy History of methadone or morphine use History of allergy to methadone or morphine A history of recent use of any opiates or alcohol Patients who, for any reason, require prolonged intubation after surgery.

Design outcomes

Primary

MeasureTime frame
Pain intensity. Timepoint: Measurements at 1, 2, 6, 12, 24, and 48 hours after intervention injection. Method of measurement: Visual Analogue Scale.

Secondary

MeasureTime frame
Sedation level on. Timepoint: Measurements at 1, 2, 6, 12, 24, and 48 hours after intervention injection. Method of measurement: Collins and Reed Attachment Style Questionnaire (RAAS).

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNafiseh Faghani Makrani

Mazandaran University of Medical Sciences

dr.nfaghani@gmail.com+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026