Effect of tacrolimus drops and PRP in the treatment of chronic dry eye

Simultaneous effect of tacrolimus drops and PRP and its comparison with artificial tacrolimus drops in the treatment of chronic dry eye in patients referred to the hospital

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211011052725N1

Enrollment

Registered

2021-12-24

Start date

2022-01-10

Completion date

Unknown

Last updated

2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dry eye syndrome. Dry eye syndrome

Interventions

Intervention 1: Intervention group 1: Patients receive only artificial tear drops. Patients will use one drop three times a day, each time at eight-hour intervals. 10 ml drops will be for a patient's

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients over 18 years Corneal staining Schirmer test is less than 5 mm in 5 minutes BUT test is less than 5 seconds.

Exclusion criteria

Exclusion criteria: Pregnancy Lactation Pregnancy, lactation, history of glaucoma and previous surgery and trauma Use of eye drops other than artificial tears, and use of contact lenses.

Design outcomes

Primary

Measure	Time frame
BUT test (Fluorescein disappears from Fornix). Timepoint: One week, one month and three months after starting treatment. Method of measurement: Clinical examination of the patient - per second.;Corneal staining. Timepoint: One week, one month and three months after starting treatment. Method of measurement: Clinical examination of the patient.;Schirmer test. Timepoint: One week, one month and three months after starting treatment. Method of measurement: Clinical examination of the patient - In millimeters per minute.	—

Measure

Time frame

BUT test (Fluorescein disappears from Fornix). Timepoint: One week, one month and three months after starting treatment. Method of measurement: Clinical examination of the patient - per second.;Corneal staining. Timepoint: One week, one month and three months after starting treatment. Method of measurement: Clinical examination of the patient.;Schirmer test. Timepoint: One week, one month and three months after starting treatment. Method of measurement: Clinical examination of the patient - In millimeters per minute.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarzaneh Barzegarpur

Kerman University of Medical Sciences

barzegarf1368@yahoo.com+98 34 3428 2227

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026