Evaluation of the effect of desloratadine in the treatment of acne

Comparison of the effect of oral isotretinoin with isotretinoin and des loratadine in the treatment of moderate and severe acne vulgaris

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211010052723N1

Enrollment

Registered

2021-11-18

Start date

2021-11-21

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acne vulgaris. Acne vulgaris

Interventions

Intervention 1: Intervention group: Patients undergoing standard treatment for moderate to severe acne, including isotretinoin capsule (PHARMATHEN ACNOTREN) 20mg daily and clindamycin 1% solution (man

Eligibility

Sex/Gender

All

Age

15 Years to No maximum

Inclusion criteria

Inclusion criteria: Patient consent to participate in the study Age over 15 years No history of allergy to retinoid compounds Do not take oral medications to treat acne for the past 2 months

Exclusion criteria

Exclusion criteria: liver or kidney disease and dyslipidemia pregnancy or desire to get pregnant breastfeeding

Design outcomes

Primary

Measure	Time frame
Acne Score with GAGS (Global Acne Grading System). Timepoint: Evaluation of acne lesions before receiving the drug and at weeks 8, 16 and 24. Method of measurement: In the Global Acne Grading System 19 to 30 are considered moderate, 31-38 severe and above 38 very severe.;Evaluation of the side effects of isotretinoin [dry skin, lips (Mild, moderate and severe), dry eyes, nosebleeds, and hair loss]. Timepoint: at weeks 8, 16 and 24. Method of measurement: Asking the patients.	—

Measure

Time frame

Acne Score with GAGS (Global Acne Grading System). Timepoint: Evaluation of acne lesions before receiving the drug and at weeks 8, 16 and 24. Method of measurement: In the Global Acne Grading System 19 to 30 are considered moderate, 31-38 severe and above 38 very severe.;Evaluation of the side effects of isotretinoin [dry skin, lips (Mild, moderate and severe), dry eyes, nosebleeds, and hair loss]. Timepoint: at weeks 8, 16 and 24. Method of measurement: Asking the patients.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahya Abedini

Esfahan University of Medical Sciences

Aabedini.ma@gmail.com+98 31 3621 8308

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026