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Comparison of the effect of intravenous and oral acetaminophen in the prevention of delirium

Comparison of the Effect of intravenous Acetaminophen and oral Acetaminophen in the Prevention of Delirium in the Elderly After Heart Surgery

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20211010052718N1
Enrollment
64
Registered
2021-11-20
Start date
2020-02-29
Completion date
Unknown
Last updated
2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Prevention of delirium in the elderly after heart surgery. Delirium due to known physiological condition

Interventions

Intervention 1: Intervention group:Intravenous acetaminophen 1 g of Galenus's product is given within one hour after ICU admission and every 8 hours after surgery and continues until the first 48 hour

Sponsors

Mazandaran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
60 Years to No maximum

Inclusion criteria

Inclusion criteria: Patients who are at least 60 years old and undergo heart surgery

Exclusion criteria

Exclusion criteria: Preoperative ventricular ejection fraction less than 30% Emergency method Aortic dissection surgery Pre-existing cognitive dysfunction Parkinson's disease Alzheimer's disease Recent seizures (less than 3 months), taking prophylactic medications for cognitive decline Serum creatinine greater than 2 mg / dL Liver dysfunction (liver enzymes more than four times basal) Alcohol or drug abuse (more than 10 drinks per week) Allergy to any of the studied drugs

Design outcomes

Primary

MeasureTime frame
Delrium after surgery. Timepoint: The first 48 hours after surgery continue. Method of measurement: Visual Analogue Scale.

Secondary

MeasureTime frame
The length of stay in the intensive care unit and hospital. Timepoint: After clearance. Method of measurement: Hospital file.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactJavad Taziki

Mazandaran University of Medical Sciences

javadtazikii@gmail.com+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026