Comparison of the efficacy of oral Acetaminophen and oral Ibuprofen for treatment of preterm with patent ductus arteriosus

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211010052715N1

Enrollment

Registered

2021-11-25

Start date

2021-04-21

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Patent ductus arteriosus (PDA). Patent ductus arteriosus

Interventions

Intervention 1: Intervention group: Includes premature neonates with PDA diagnosis by pediatric cardiologist. In this group, samples (n=30) received oral Acetaminophen at a dose of 15mg / kg every 8 h

Eligibility

Sex/Gender

All

Age

1 Days to 3 Days

Inclusion criteria

Inclusion criteria: Parent's consent to participate in the study Gestational age 26 to 37 weeks Diagnosis of ductus arteriosus based on echocardiographic evidence at 24 to 72 hours after birth

Exclusion criteria

Exclusion criteria: Premature newborn with fever and seizure Life-threatening infections, Clinical or radiographic evidence of necrotizing enterocolitis Evidence of bleeding Platelets less than 50,000 per ml Liver failure Congenital brain-neurological disorders, Metabolic and genetic syndromes Pulmonary hypoplasia syndrome Congenital heart anomalies or other fatal abnormalities

Design outcomes

Primary

Measure	Time frame
PDA size. Timepoint: Before and after the intervention. Method of measurement: Echocardiography by pediatiric's cardiologist .	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactZahra Hadadi

Iran University of Medical Sciences

hadadi.za@iums.ac.ir+98 21 2304 6253

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026