Depression. Mood disorder due to known physiological condition with major depressive-like episode
Conditions
Interventions
Intervention 1: Intervention group: Combination of thiopental at a dose of 3 mg / kg with ketamine at a dose of 0.5 mg / kg after administration of 0.5 mg atropine at the beginning of ECT. Interventio
Sponsors
Semnan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Includes: Diagnosis of moderate to severe depression episode affected by DSM-5 age at least 18 years performance and willingness to provide written consent by patient or legal guardian verbal IQ of 8.5 or greater undergoing ECT treatment in the past six months To be caught
Exclusion criteria
Exclusion criteria: Inability to provide informed written consent in the absence of a legal guardian primary psychotic or schizoaffective disorder obsessive-compulsive disorder concomitant diagnosis of multiple psychiatric disorders in axis one and two anorexia nervosa history of substance or alcohol dependence sensitivity to Anesthesia drugs or contraindications for their administration ECT in the last three months contraindications for ECT such as organic brain diseases and dementia major medical conditions that affect neuropsychological function pregnancy or lack of proper contraception breastfeeding Occurrence of psychotic symptoms or exacerbation of depressive symptoms during the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Depression score in Beck questionnaire. Timepoint: Before the start of the first ECT session and at the end of the third and sixth sessions, the Beck Depression Inventory test is performed on all samples. Method of measurement: Beck Depression Inventory. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of life score. Timepoint: After the end of the treatment period. Method of measurement: Short questionnaire SF-12. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAysan Taravati
Semnan University of Medical Sciences
Outcome results
None listed