Evaluation of the anti-anxiety effect of ketamine

Comparative study of the anxiolytic effect of oral ketamine and fluvoxamine in the treatment of children with separation anxiety disorder leads to school avoidance referral to subspecialty medical centers for child and adolescent psychiatry

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20211004052670N3

Enrollment

100

Registered

2022-06-29

Start date

2021-11-22

Completion date

Unknown

Last updated

2022-08-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Separation anxiety disorder leads to school refusal. Separation anxiety disorder of childhood

Interventions

Intervention 1: Intervention group: Ketamine is started at a dose of 0.1 mg / kg and on weekly visits based on patient tolerance 0.1 mg / kg is increased to a maximum dose of 1 mg / kg. Intervention 2

Eligibility

Sex/Gender

All

Age

6 Years to 10 Years

Inclusion criteria

Inclusion criteria: Children aged 6 to 10 years Diagnosis of separation anxiety disorder leads to school avoidance Conscious consent to participate in the study No suicidal plans or thoughts at the time of enrollment Living in Isfahan

Exclusion criteria

Exclusion criteria: Existence of psychiatric comorbid disorders

Design outcomes

Primary

Measure	Time frame
Anxiety score based on CATS and SCARED questionnaires. Timepoint: Before treatment and the eighth and sixteenth week. Method of measurement: Childhood Automatic Thought Scale and Screen for Child Anxiety Related Emotional Disorders questionnaires.	—

Countries

Iran (Islamic Republic of)

Contacts

Public Contactfarzaneh hosseini

Esfahan University of Medical Sciences

farzanehoseini@gmail.com+98 31 3230 3972

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026