Comparison of the effect of peri-articular injection of dextrose and corticosteroid with dextrose alone on pain relief in patients with knee osteoarthritis.

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210930052641N1

Enrollment

Registered

2022-01-20

Start date

2022-01-21

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Primary osteoarthritis, unspecified site

Interventions

Intervention 1: In the intervention group (group receiving 20% dextrose alone), both legs will be injected into the periarticular area. Dextrose 0.5 cc Dextrose 20% in combination with 0.5 cc lidocain

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: Existence of at least three of the six ACR criteria: 1. Age over 50 years, 2. Morning stiffness less than 30 minutes, 3. Cryptation sensation in active knee movements, 4. Bone sensitivity, 5. Bone enlargement, 6. Absence of warmness at the touch of the joint Evidence for osteoarthritis on knees radiography Grade 2 or 3 osteoarthritis based on the Kellgren-Lawrence index

Exclusion criteria

Exclusion criteria: Previous therapeutic injection with dextrose Use of braces or NSAIDs or daily use of opioids during the study Pregnancy, Lactation Contraindication to corticosteroid injection History of metabolic bone disease, coagulation disorders Injection of steroid drugs in the last 2 months History of joint fracture History of inflammatory joint disease, post-infection arthritis, joint dysplasia, congenital anomalies, crystallopathy, post-traumatic arthritis, malignancy, vascular necrosis Obesity BMI>30 Knee infection in the last three months or knee inflammation Candidate patients for knee surgery Diabetes

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).;Knee fatigue. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).;Physical function. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).	—

Measure

Time frame

Pain. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).;Knee fatigue. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).;Physical function. Timepoint: Before intervention , 1 month after one intervention and 3 months after one intervention. Method of measurement: using questionnaire (Western Ontario & McMaster Universities Osteoarthritis Index ).

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShirin Nourbakhsh

Sanandaj University of Medical Sciences

shrn.nourbakhsh@gmail.com+98 87 3328 6112

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026