diabetic peripheral neuropathy. Type 2 diabetes mellitus with neurological complications
Conditions
Interventions
Intervention 1: Intervention group: vitamin B12 500 mcg EuRovital (twice a day),The patients will be received 1 tablet of 500 mcg of vitamin B12 two times daily for 4 months. Intervention 2: Intervent
Sponsors
Tehran University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 70 Years
Inclusion criteria
Inclusion criteria: Patients will eligible for recruitment with a MNSI of 2 or higher, abnormal NCS results age 30-70 years old low levels of vitamin B12
Exclusion criteria
Exclusion criteria: current pregnancy or lactating women, alcohol intake, current smoker, diabetic foot mental disease, heart failure, cancer evidence of liver disease (such as viral hepatitis, autoimmune hepatitis, etc.) impaired renal (GFR 9%)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Michigan neuropathy screening instrument (MNSI). Timepoint: Baseline and 16 weeks. Method of measurement: Using standard scoring systems and questionnaires. Scoring is: Michigan neuropathy screening instrument , (0-10).;Neuropathy disability score (NDS). Timepoint: Baseline and 16 weeks. Method of measurement: Using standard scoring systems and questionnaires. Scoring is: Neuropathy disability score (0-10).;Pain score. Timepoint: Baseline and 16 weeks. Method of measurement: Patients will be asked to score pain on a visual analog scale 0-10 with 10 being the worst pain ever.;Fasting glucose and HBA1c. Timepoint: Baseline and 16 weeks. Method of measurement: lab kit.;Lipid profiles (HDL-c, LDL-c, TG, TC). Timepoint: Baseline and 16 weeks. Method of measurement: lab kit. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAsieh Mansour
Tehran University of Medical Sciences
Outcome results
None listed