Evaluation the effect of nasal irrigation with gentamicin after sinus surgery

Evaluation of the Effect of Gentamicin Nasal Irrigation on Clinical Symptoms, Radiological and Endoscopic Scores Following Sinus Surgery in Patients with Chronic Rhinosinusitis with Bilateral Nasal and Sinus Polyposis

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210923052559N4

Enrollment

Registered

2025-04-23

Start date

2025-05-10

Completion date

Unknown

Last updated

2025-07-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic rhinosinusitis with bilateral nasal polyps. Chronic pansinusitis

Interventions

Intervention 1: Intervention group: In this group, patients will use a nasal wash solution containing 80 mg of gentamicin in 25 cc of normal saline in each nostril three times a day for 6 weeks after

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with chronic rhinosinusitis with bilateral nasal and sinus polyps based on EPOS2020 diagnostic criteria Lack of adequate response despite 8 weeks of standard medical treatment Informed consent for participation in the study

Exclusion criteria

Exclusion criteria: Use of antibiotics other than those prescribed post-surgery Renal failure Systemic immune deficiency Pregnancy Breastfeeding Asthma Allergy to aspirin

Design outcomes

Primary

Measure	Time frame
Improvement in clinical symptoms. Timepoint: Before surgery and six weeks after surgery. Method of measurement: Based on the SNOT22 questionnaire.;Endoscopic evaluation of the nose. Timepoint: Before surgery and six weeks after surgery. Method of measurement: Nasal endoscopy and using the LUND-KENNEDY criteria.;Radiological evaluation of the nose. Timepoint: Before surgery and six weeks after surgery. Method of measurement: CT scan of the nose and using the LUND-MACKAY criteria.	—

Measure

Time frame

Improvement in clinical symptoms. Timepoint: Before surgery and six weeks after surgery. Method of measurement: Based on the SNOT22 questionnaire.;Endoscopic evaluation of the nose. Timepoint: Before surgery and six weeks after surgery. Method of measurement: Nasal endoscopy and using the LUND-KENNEDY criteria.;Radiological evaluation of the nose. Timepoint: Before surgery and six weeks after surgery. Method of measurement: CT scan of the nose and using the LUND-MACKAY criteria.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMohammadreza Majidi

Mashhad University of Medical Sciences

MajidiMR@mums.ac.ir+98 51 3801 2649

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026