Knee osteoarthritis. Osteoarthritis, unspecified site
Conditions
Interventions
Intervention 1: Intervention group: Patients in this group will take two black seed capsules per day (every 12 hours) for 3 months.Each capsule of black seed contains 5.3 mg of thymoquinone, the effec
Sponsors
Mashhad University of Medical Sciences
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Knee osteoarthritis Satisfaction to enter the study
Exclusion criteria
Exclusion criteria: Taking medicine for osteoarthritis of the knee Having an infection or primary inflammatory disease in the knee joint Arthritis caused by crystals Intra-articular tumors Knee joint ligament instability Previous intra-articular fracture Knee joint surgery (arthroscopic or otherwise) in the last 12 months Injection of any intra-articular drug in the last 3 months Existence of simultaneous severe diseases (metabolic diseases and history of stroke in the past)
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The amount of pain in the knee area. Timepoint: At the beginning of the study (before the start of the intervention) and 1, 2 and 3 months after the start of black seed oil capsules. Method of measurement: WOMAC questionnaire.;Tenascin-C serum level. Timepoint: At the beginning of the study (before the start of intervention) and 3 months after the start of taking black seed oil capsules. Method of measurement: ELISA method using the Tenascin-c kit from Zellbio GmbH company. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMandana Khodashahi
Mashhad University of Medical Sciences
Outcome results
None listed