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Inhalation of stem cell products in patients with covid-19

Evaluation of the therapeutic effect of nebulized addipose tissue- derived mesenchymal stem cells conditioned media on covid -19 pneumonia

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210919052520N1
Enrollment
15
Registered
2022-01-13
Start date
2021-11-22
Completion date
Unknown
Last updated
2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

covid-19. https://www.who.int/publications/m/item/covid-19-update-for-icd-10

Interventions

Intervention 1: Intervention group: Includes 15 patients who will receive the conditioned-medium by nebulization for 8 days in two doses at 8:30 in the morning and 4 in the afternoon. Intervention 2:

Sponsors

Kerman University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
No minimum to 60 Years

Inclusion criteria

Inclusion criteria: Patients with Covid 19 who have been infected for a week and who have been hospitalized for 48 hours despite receiving medication and oxygen have not improved their condition and their arterial blood oxygen saturation percentage is below 88%.

Exclusion criteria

Exclusion criteria: Patients with arterial blood oxygen saturation above 88%.

Design outcomes

Primary

MeasureTime frame
Treatment of patients suffer from Covid 19 nebulization of conditioned-medium derived from human adipose tissue mesenchymal stem cell. Timepoint: Comparison of the improvement of patients with covid-19 disease before the intervention and after 5 days of therapeutic intervention. Method of measurement: blood laboratory test , CT-Scan.

Secondary

MeasureTime frame
Reduction of lung damage. Timepoint: Measurement of lung damage before and after therapeutic intervention. Method of measurement: CT-Scan.;CRP, LDH, WBC measurement. Timepoint: Before and after therapeutic intervention. Method of measurement: blood laboratory test.;Fever. Timepoint: Before and after therapeutic intervention. Method of measurement: Thermometer.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMona Saheli

Kerman University of Medical Sciences

saheli.mona@gmail.com+98 34 3325 7666

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026