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Assessment of the amniotic membrane effect in anal fissure wound

Assessment of the amniotic membrane effect on healing of anal fissure wound after surgery

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210919052515N3
Enrollment
110
Registered
2022-02-13
Start date
2022-02-20
Completion date
Unknown
Last updated
2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Fissure wound. Fissure and fistula of anal and rectal regions

Interventions

Intervention 1: Intervention group: in addition to standard sphincterotomy surgery, two Cm2 of amniotic membrane prepared from the stem cell center of the Tehran University will be sutured to the marg

Sponsors

Oroumia University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients with anal fissures Patients with no recovery despite treatment with fiber, topical ointment and hot tub for more than 3 weeks Having pain during defecation

Exclusion criteria

Exclusion criteria: History of inflammatory bowel disease Past medical history of previous anal surgeries BMI>30 kg/m2 Autoimmune diseases

Design outcomes

Primary

MeasureTime frame
Wound healing. Timepoint: 1, 2, 3 and 4 weeks after surgery. Method of measurement: Clinical examination.;Duration of pain. Timepoint: Up to 4 weeks after surgery. Method of measurement: The number of days with pain.

Secondary

MeasureTime frame
Wound infection. Timepoint: 1, 2, 3 and 4 weeks after surgery. Method of measurement: Clinical examination.;Pruritus of wound. Timepoint: 1, 2, 3 and 4 weeks after surgery. Method of measurement: Clinical examination.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr. Naser Masoudi

Oroumia University of Medical Sciences

masoudi.n@umsu.ac.ir+98 44 3198 8293

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026