Colon cancer. Malignant neoplasm of colon
Conditions
Interventions
Intervention 1: Intervention group: Patients will be received the ketogenic diet for three months in addition to the standard chemotherapy protocol. The ketogenic diet is a low-carb, high-fat diet. Th
Sponsors
Oroumia University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: Patients with stage 4 of colorectal cancer Age over 18 years
Exclusion criteria
Exclusion criteria: Lipid metabolism disorders such as carnitine deficiency Patients with liver failure Metastasis to more than 50% in liver tissue History of gastric and pancreatic surgeries Renal cell carcinoma Type 1 diabetes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment including primary tumor and metastasis size before and after the intervention. Timepoint: Before and three months after the intervention. Method of measurement: With CT scan imaging in millimeters. | — |
Secondary
| Measure | Time frame |
|---|---|
| Ketone body. Timepoint: Before and three months after the intervention. Method of measurement: Ketone meter in blood serum (mM/L).;Carcinoembryonic antigen (CEA). Timepoint: Before and three months after the intervention. Method of measurement: ELISA test (ng/mL).;Vascular endothelium growth factor expression (VEGF). Timepoint: Before and three months after the intervention. Method of measurement: Blood serum (Pg/mL).;C-Reactive Protein (CRP). Timepoint: Before and three months after the intervention. Method of measurement: Blood serum (mg/L). | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactDr.Naser Masoudi
Oroumia University of Medical Sciences
Outcome results
None listed