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Assessment of the efficacy of topical gel containing insulin and silver nanoparticles in the treatment of second-degree burn wounds

Comparison of the efficacy of using topical gel containing insulin and silver nanoparticles and topical gel containing silver nanoparticles on the duration of complete wound healing in patients with second-level burn wounds: a double-blind and randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210918052511N3
Enrollment
56
Registered
2022-11-23
Start date
2022-11-21
Completion date
Unknown
Last updated
2023-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Burn patients. Burn and corrosion of head, face, and neck

Interventions

Intervention 1: Intervention group: The topical gel containing insulin and silver nanoparticles is used for two weeks and this dressing in the treatment of burn wounds accelerates wound healing, reduc

Sponsors

Mashhad University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
2 Years to 60 Years

Inclusion criteria

Inclusion criteria: Patients between the ages of 2 and 60 are eligible to participate. Patients with second-degree burns diagnosed by the relevant physician Patients with burns that are less than or equal to 20% Patient with second-degree burns in upper and lower limbs and anterior trunk The wound is examined by a plastic and burn surgeon for necrosis and the depth of the burn. If the burned area is not a candidate for early surgery and can be healed without surgery and with minimal complications, the patient will be eligible to the study

Exclusion criteria

Exclusion criteria: Delayed visit and the presence of obvious wound infection at the first visit by an infectious disease specialist Patients who are receiving chemotherapy Patients taking corticosteroids or cytotoxic medicines Pregnancy Cancer, cytotoxic drugs, immunosuppressants, and the presence of chronic diseases other than diabetes that affect wound healing, such as severe vascular disease, lupus, rheumatoid arthritis, and renal failure Smoking The presence of an underlying disease leads to a defective immune system Diabetic patients Taking drugs that lead to a defective immune system. Burns in the back of the trunk, face, head and perineum

Design outcomes

Primary

MeasureTime frame
Duration of complete wound healing. Timepoint: Every 48 hours. Method of measurement: Based on the clinical observations of an infectious disease specialist and plastic and burn surgeon.

Secondary

MeasureTime frame
Wound condition (presence or absence of granulation tissue, bleeding, pain, infection, and other wound complications or healing factors). Timepoint: Every 48 hours for 2 weeks. Method of measurement: Based on the scores of the variables and presence or absence (yes / no) and based on clinical observations of an infectious disease specialist and subspecialty of plastic surgery and burns.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactDr Omid Yazarlou

Mashhad University of Medical Sciences

Yazarlouom@mums.ac.ir+98 51 3802 2051

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026