The effect of aqueous extract of pistachio pericarp on knee osteoarthritis

Effect of topical aqueous extract of pistachio (Pistacia Vera L.) pericarp on knee osteoarthritis: A randomized double-blind controlled clinical trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210912052445N1

Enrollment

Registered

2021-11-13

Start date

2022-04-21

Completion date

Unknown

Last updated

2021-11-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis. Osteoarthritis of knee

Interventions

Intervention 1: Intervention group: A: Piroxicam gel, Topical application twice a day, 8 weeks, Drug massage (3-5 minutes). Intervention 2: Intervention group: B: aqueous extract of pistachio pericarp

Eligibility

Sex/Gender

All

Age

45 Years to 70 Years

Inclusion criteria

Inclusion criteria: age 45-70 years old diagnosis of knee osteoarthritis will be based on American College of Rheumatology (ACR) criteria, which will be approved by a specialist in rheumatology the presence of moderate knee pain within 24 hours will be based on Visual Pain Scale (VAS) to 4–7 cm

Exclusion criteria

Exclusion criteria: Patients with inflammatory diseases (such as lupus, rheumatoid arthritis, a history of brucellosis, etc.) cancer or other serious diseases symptoms or history of liver or kidney failure Taking oral corticosteroids in the past 4 weeks corticosteroid injection during the last 6 months Fever continuous use of herbs smoking and drugs allergy to pistachios consuming of dietary and medicinal supplements consumption of pistachios during the two weeks before the start of the test Regular daily use of painkillers and very advanced disease use of other topical drugs at the site of drug use oral use of other analgesics and other effective compounds in the treatment of osteoarthritis up to 10 days before the study skin or infectious disease or wound at the site of drug use pregnancy

Design outcomes

Primary

Measure	Time frame
Intensity of knee pain on Visual Analogue Scale (VAS). Timepoint: Before intervention-8 weeks after intervention. Method of measurement: Visual Analogue Scale (VAS).;Knee performance in Western Ontario and Mc Master (WOMAC). Timepoint: Before intervention-8 weeks after intervention. Method of measurement: Questionnaire Western Ontario and Mc Master (WOMAC).	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSoudeh Khanamani Falahati-pour

Rafsanjan University of Medical Sciences

s.falahatipour@rums.ac.ir+98 34 3428 2703

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026