Idiopathic Male Infertility. Male infertility
Conditions
Interventions
Intervention 1: Control group: Group 1: Receiving clomiphene citrate tablets - Iran Hormone company (1 tablet of 50 mg per day) - for three months. Intervention 2: Intervention group: Group 2: Receivi
Sponsors
Gorgan University of Medical Sciences
Eligibility
Sex/Gender
Male
Age
20 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Men 20-50 years with at least one year of idopatic infertility disorder 2. Existence of at least one of the three criteria related to sperm disorder (number - motility - morphology) - Existence of idiopathic oligospermia disorder according to WHO criteria (Existence of sperm count less than 15 million per ml and total less than 39 million in semen It is called oligospermia) - Presence of idiopathic stenospermia according to WHO criteria (if the percentage of sperm with normal motility in semen is less than 40% is called stenospermia). Has a normal morphology in semen less than 4% is called teratospermia) 3. Patients with varicocele who has been 6 month since their surgery and have not been able to conceive 4. Normal testosterone, serum gonadotropins and prolactin 5. Normal thyroid hormones (no hypo or hypothyroidism) 6. BMI=30kg/m2 7. Satisfaction of the patient
Exclusion criteria
Exclusion criteria: 1- Severe oligospermia or azoospermia (less than 5 million sperm per milliliter) 2- History of epididymitis, prostatitis, trauma, testicular torsion, inguinal scrotal surgery 3- Pretesticular disorders such as endocrine diseases (hyperprolactinemia, congenital adrenal hyperplasia ...) 4- Known Testicular disorders such as varicocele or orchitis or cryptorchidism 5- Known post testicular disorders such as mechanical obstruction, impaired egg transfer or functional obstruction, vasectomy, etc. 6- History of taking anti-metabolites and alkylators 7- History of cancer and chemotherapy and radiotherapy treatments 8- Having chronic diseases such as diabetes and cardiovascular disorders 9- Infection of the genital tract 10- Taking cytotoxic, immunosuppressive, androgen or anti-androgen drugs and alcohol or opium addiction 11- Having liver failure 12- Having kidney failure 13- History of receiving medicine for infertility treatment in the last three months 14- History of receiving drugs affecting semen in the last three months
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean semen volume (cc). Timepoint: Beginning and end of the study. Method of measurement: Use a pipette or calibrated tube.;Mean sperm count per milliliter of semen. Timepoint: Beginning and end of the study. Method of measurement: Sperm analyzer and neobar slide.;Mean percentage of motile sperms. Timepoint: Beginning and end of the study. Method of measurement: Sperm analyzer device and simple slide.;Mean sperm percentage with normal morphology. Timepoint: Beginning and end of the study. Method of measurement: Sperm analyzer device and simple slide.;Sexual function. Timepoint: Beginning and end of the study. Method of measurement: Men's Sexual Health Questionnaire. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactSayed Abolhasan Mousavi Khorshidi
Gorgan University of Medical Sciences
Outcome results
None listed