Comparison of The Efficacy And Side Effects of Combined Doses of Dexmedetomidine And Propofol With Isoflurane And Nitrosoxide as a General Anesthetic Preservative in Orthopedic Surgeries

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210904052371N3

Enrollment

Registered

2022-06-20

Start date

2022-06-22

Completion date

Unknown

Last updated

2022-06-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Depth of anesthesia. Other medical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure

Interventions

Intervention 1: Intervention group: Group (A) for dexmedetomidine will use an initial bolus dose (0.5 µg / kg) over 10 minutes and a maintenance dose (0.5 µg / kg / h). Propofol will also be used in b

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Inclusion criteria

Inclusion criteria: The patient's desire to participate in the study and gain informed consent Candidate for non-emergency orthopedic surgery under general anesthesia Age between 18-60 years Class 1 and 2 Anesthesia (ASA) Patients who do not have complications such as hypotension, hypertension, bradycardia, pneumothorax, air embolism and decreased arterial oxygen saturation, which is a possible side effect of anesthetics

Exclusion criteria

Exclusion criteria: Emergency surgery Known allergies to the drugs used in the present study Operation longer than 5 hours Patients during the intervention if acute complications such as hypotension, hypertension, bradycardia, pneumothorax, air embolism and a decrease in arterial oxygen saturation.

Design outcomes

Primary

Measure	Time frame
Time to wake up from anesthesia. Timepoint: From the moment of closing the anesthetic (inhaled or intravenous) to the moment of waking the patient if the patient is able to obey instructions and communicate. Method of measurement: Visual Analogue Scale.	—

Secondary

Measure	Time frame
Depth of anesthesia. Timepoint: Immediately before and after induction (before starting maintenance dose), while receiving maintenance dose, when discontinuing anesthesia, moment of awakening from anesthesia, end of recovery. Method of measurement: brain function assessment.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactGoli Azzi

Mazandaran University of Medical Sciences

Gaezi@mazums.ac.ir+98 11 3336 1700

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026