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Evaluation of the efficacy of Hydroxyurea administration on blood oxygen saturation of COVID-19 patients

Evaluation of the efficacy of Hydroxyurea administration on blood oxygen saturation of hospitalized patients with severe COVID-19

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210901052358N2
Enrollment
10
Registered
2022-03-08
Start date
2022-03-21
Completion date
Unknown
Last updated
2022-04-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

COVID-19. COVID-19, virus identified

Interventions

Intervention group: This study is performed on only one group of patients who all receive hydroxyurea tablets (500 mg three times a day) in addition to the usual COVID-19 treatments according to the n

Sponsors

Shahid Beheshti University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Laboratory confirmation of Coronavirus disease-19 (COVID-19) virus by reverse transcription- polymerase chain reaction (RT-PCR) Oxygen saturation less than 90% Respiratory rate more than 24 per minute More than 50% involvement of the lung parenchyma on CT scan

Exclusion criteria

Exclusion criteria: White blood cell count less than 2500 million cells per microliter Absolute neutrophil count less than 1000 million cells per microliter Platelet count less than 80,000 cells per microliter More than 50% increase in creatinine compared to the amounts of admission time Pregnancy Active hepatitis B or C infections

Design outcomes

Primary

MeasureTime frame
Peripheral blood oxygen saturation. Timepoint: Every other day after starting treatment (up to a week). Method of measurement: Pulseoxymeter.;Hemoglobin F levels. Timepoint: Every other day after starting treatment (up to a week). Method of measurement: Hemoglobin electrophoresis.;Blood cell count. Timepoint: Every other day after starting treatment (up to a week). Method of measurement: Laboratory report.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAmirreza Keyvanfar

Shahid Beheshti University of Medical Sciences

amirrezakeyvanfar@yahoo.com+98 21 4483 1899

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026