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: Efficacy of gonioscopy-assisted transluminal trabeculotomy surgery in advanced open-angle glaucoma

Evaluation of the effectiveness of gonioscopy-assisted transluminal trabeculotomy (GATT) surgery in patients with advanced open-angle glaucoma and comparison of intraocular pressure and glaucoma control in patients before and after surgery.

Status
Recruiting
Phases
Phase 2
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210901052357N3
Enrollment
35
Registered
2025-08-02
Start date
2025-07-21
Completion date
Unknown
Last updated
2025-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

glaucoma. Glaucoma

Interventions

Intervention group:Patients with advanced open-angle glaucoma whose intraocular pressure is not controlled despite medication..

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: -All patients over the age of 18 who have advanced open-angle glaucoma based on examinations, gonioscopy, and imaging findings. -All patients with advanced open-angle glaucoma, including all types of open-angle glaucoma, whether primary or secondary, pigmentary or exfoliative glaucoma, will be included in the study. -Patients with advanced open-angle glaucoma are patients who have a cup-to-disc ratio equal to or greater than 0.9 and whose intraocular pressure is not controlled by full-dose treatment with intraocular pressure-lowering medications. - Patients with advanced open-angle glaucoma whose intraocular pressure is between 20 and 30 despite taking medications and drops that lower intraocular pressure.

Exclusion criteria

Exclusion criteria: -Patients with angle-closure glaucoma -Patients with mild or moderate open-angle glaucoma and intraocular pressure controlled with eye pressure-lowering medications. -Patients with advanced open-angle glaucoma whose intraocular pressure is higher than 30 despite taking medications and eye drops that lower intraocular pressure.

Design outcomes

Primary

MeasureTime frame
Intraocular pressure. Timepoint: First day, first week, first month, third month and sixth month after surgery. Method of measurement: Using the Goldman slit lamp tonometry device.

Secondary

MeasureTime frame
Number of antiglaucoma medications used. Timepoint: In the first week, first month, third month, and sixth month after surgery. Method of measurement: Number of medications and drops used to control intraocular pressure based on the number of medications.;Review of complications of GATT surgery. Timepoint: From the first day of surgery to the sixth month after surgery. Method of measurement: Complications of the procedure are listed according to their type and extent.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFarhad Najafzadeh

Tabriz University of Medical Sciences

najafzadeh.farhad@gmail.com+98 41 3657 7336

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026