The effect of intravenous vitamin C infusion on improvement of cerebral blood flow of diabetic patients and evaluation of brain oxygenation with a cerebral oximeter during general anesthesia in vascular surgery

The effect of intravenous vitamin C infusion and evaluation of brain oxygenation with a cerebral oximetry in improving brain perfusion of diabetic patients during general anesthesia in vascular surgery

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210830052345N1

Enrollment

Registered

2021-09-23

Start date

2021-09-05

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vascular surgery (carotid endarterectomy). Vascular syndromes of brain in cerebrovascular diseases

Interventions

Intervention 1: Intervention group or vitamin C: They will receive an infusion of 1 gr of vitamin C diluted in 500 ml of isotonic saline, half an hour before induction of anesthesia. Intervention 2:

Eligibility

Sex/Gender

All

Age

50 Years to No maximum

Inclusion criteria

Inclusion criteria: Diabetic patients who are candidates for vascular surgery Having the consent to participate in the project Age 50 years and older ASA Class II

Exclusion criteria

Exclusion criteria: Patients with dissatisfaction with participation in the plan ASA class III and above Hemoglobin level less than 8 g/dl Brain failure Metabolic disease Any type of intracranial pathology

Design outcomes

Primary

Measure	Time frame
Blood pressure. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Barometer (Non-Invasive Blood Pressure).;Heart rate. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cardiac monitoring.;Blood sugar. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Glucometer.;EtCO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.;RSO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.;ScO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.;SpO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Pulse oximetry.;PaCo2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.	—

Measure

Time frame

Blood pressure. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Barometer (Non-Invasive Blood Pressure).;Heart rate. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cardiac monitoring.;Blood sugar. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Glucometer.;EtCO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.;RSO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.;ScO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.;SpO2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Pulse oximetry.;PaCo2. Timepoint: Before and after Anesthesia induction and measurement at the end of the operation. Method of measurement: Cerebral oximetry.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactNavid Tavakoli

Shahid Beheshti University of Medical Sciences

navidtavakoli@sbmu.ac.ir+98 21 2282 4929

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026