Effect of reduce microbial load on lupus activity

Comparison of efficacy between SRP with CHX mouthwash and SRP with caries removal in SLE activity

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210830052341N1

Enrollment

Registered

2021-09-14

Start date

2020-10-01

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Systemic lupus Erythematosus. Systemic lupus erythematosus (SLE)

Interventions

Intervention 1: Intervention group: Non-surgical periodontal treatments include SRP and chlorhexidine 0.2% mouthwash to reduce the microbial load. Intervention 2: Intervention group: Non-surgical peri

Eligibility

Sex/Gender

Female

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: SLE parients At least has 6 teeth There is no other systemic disorder

Exclusion criteria

Exclusion criteria: other systemic diseases such as diabetes pregnancy

Design outcomes

Primary

Measure	Time frame
Systemic Lupus Erythematosus Activity Index. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: clinical criteria check list.;Erythrocyte sedimentation rate. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: laboratory test.;C - reactive protein. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: laboratory test.;Visual analogue scale. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: visual Analogue.	—

Measure

Time frame

Systemic Lupus Erythematosus Activity Index. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: clinical criteria check list.;Erythrocyte sedimentation rate. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: laboratory test.;C - reactive protein. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: laboratory test.;Visual analogue scale. Timepoint: Before intervention , 2 and 4 months after intervention. Method of measurement: visual Analogue.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactShahmiri Atefe

Birjand University of Medical Sciences

atefeshah5@gmail.com+98 51 3864 0826

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026