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The effect of 1% pilocarpine mouthwash on salivation in patients undergoing head and neck radiotherapy: a double-blind randomized clinical trial

The effect of 1% pilocarpine mouthwash on salivation in patients undergoing head and neck radiotherapy: a double-blind randomized clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210830052335N1
Enrollment
62
Registered
2021-09-09
Start date
2021-09-23
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Xerostomia.

Interventions

Intervention 1: Intervention group: In the case group, in addition to massage therapy training, pilocarpine hydrochloride mouthwash will be distributed, which will gargle 30 drops for 2 minutes four t

Sponsors

Tabriz University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 60 Years

Inclusion criteria

Inclusion criteria: Head and neck cancers. Topical laryngeal cancer, hypopharyngeal cancer and nasopharyngeal cancer Under conventional radiation therapy with doses greater than 50 g Satisfaction to participate in the study

Exclusion criteria

Exclusion criteria: Changes in the patient's treatment protocol or process of receiving radiation therapy Lack of patient cooperation in the study process Taking any medication that reduces salivation, physical systemic diseases such as Sjogren's syndrome, diabetes, Behcet's disease, hypertension and hyperthyroidism

Design outcomes

Primary

MeasureTime frame
Salivation rate. Timepoint: Two weeks before the first (basic) radiotherapy session, the first day of radiation therapy and two and four weeks after radiation therapy. Method of measurement: For this purpose, the spitting method will be used in which patients refrain from drinking or eating anything for 90 minutes before sampling. Then, for 5 minutes, people will be asked to empty their saliva into a calibrated test tube once or twice a minute. The amount of saliva (ml in 5 minutes) will be calculated and recorded.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactParia Motahari

Tabriz University of Medical Sciences

paria.motahari@yahoo.com+98 41 3334 7422

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026