Effect of probiotics onthyroid function and fatigue score in patients with hypothyroidism

Effect of probiotics on thyroid function and fatigue score in patients with hypothyroidism

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210829052320N1

Enrollment

Registered

2022-02-24

Start date

2022-04-21

Completion date

Unknown

Last updated

2022-03-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hypothyroidism. Central hypothyroidism

Interventions

Intervention 1: Intervention group: Lactocar 500 mg probiotic capsules once a day for 12 weeks. Intervention 2: Control group: 500mg placebo capsules for 12 weeks, 1 capsule daily.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Hypothyroid or subclinical hypothyroid patient with treatment indication At least 3 month on levothyroxine Euthyroid during this 3month

Exclusion criteria

Exclusion criteria: Recent thyroidectomy Using Antibiotics in last 3 month Being Alcohol user or smoker Being peregnant or breastfeeding Using drugs lowering levothyroxine consumption Changing levothyroxine doses during follow up time

Design outcomes

Primary

Measure	Time frame
Serum TSH levels. Timepoint: Before the intervention and after 12 weeks of medication. Method of measurement: blood test.;Serum free T4 levels. Timepoint: Before the intervention and after 12 weeks of medication. Method of measurement: Blood test.;Serum free T3 levels. Timepoint: Before the intervention and after 12 weeks of medication. Method of measurement: Blood test.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMina Akbari Rad

Mashhad University of Medical Sciences

akbariradm@mums.ac.ir+98 51 3802 2370

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026