Comparisson of the Efficacy of Ringer's Lactate Serum as a Base Solution in Modified Del Nido Cardioplegia with Standard Del Nido Cardioplegia on the Outcomes in Patients Undergoing Coronary Artery Bypass Graft

Comparisson of the Efficacy of Ringer's Lactate Serum as a Base Solution in Modified Del Nido Cardioplegia with Standard Del Nido Cardioplegia on Myocardial Damage Markers and Clinical Outcomes in Patients Undergoing Coronary Artery Bypass Graft

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210825052284N1

Enrollment

Registered

2022-09-28

Start date

2022-10-23

Completion date

Unknown

Last updated

2022-11-21

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Coronary artery bypass graft. Mechanical complication of coronary artery bypass graft and biological heart valve graft

Interventions

Intervention 1: Intervention group A: In this study, Ringer's lactate solution is used to cardioplegia in group A (modified Del Nino). Intervention 2: Intervention group B: In this study, plasmalit A

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: Candidate patients for coronary artery bypass graft Candidate patients for 3 to 4 vascular grafts Age between 18 and 75 years Written informed consent to participate in the study An ejection fraction higher than 35% before surgery Lack of multi-organ failure before surgery

Exclusion criteria

Exclusion criteria: Re-operation Proven infection or inflammation within the last month

Design outcomes

Primary

Measure	Time frame
Ejection fraction. Timepoint: Before surgery, after surgery, and 24 hours after admission to the intensive care unit. Method of measurement: Echocardiography.;Duration of mechanical ventilation. Timepoint: Daily after surgery. Method of measurement: Medical record of the patients.;Arrhythmia incidence. Timepoint: Daily after surgery. Method of measurement: Electrocardiogram device and cardiologist's interpretation.;Inotrope administration. Timepoint: Daily after surgery. Method of measurement: Medical record of the patients.	—

Measure

Time frame

Ejection fraction. Timepoint: Before surgery, after surgery, and 24 hours after admission to the intensive care unit. Method of measurement: Echocardiography.;Duration of mechanical ventilation. Timepoint: Daily after surgery. Method of measurement: Medical record of the patients.;Arrhythmia incidence. Timepoint: Daily after surgery. Method of measurement: Electrocardiogram device and cardiologist's interpretation.;Inotrope administration. Timepoint: Daily after surgery. Method of measurement: Medical record of the patients.

—

Secondary

Measure	Time frame
Troponin level. Timepoint: Before surgery, after surgery, and 24 hours after admission to the intensive care unit. Method of measurement: Laboratory report.;Lactate dehydrogenase level. Timepoint: Before surgery, after surgery, and 24 hours after admission to the intensive care unit. Method of measurement: Laboratory report.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSalimeh Janghorban

Shahid Beheshti University of Medical Sciences

Sali.cardiology@yahoo.com+98 21 7757 9045

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026