Skip to content

The effect of anti-inflammatory drug and acetaminophen on postpartum hypertension

Comparison of the effect of nonsteroidal anti-inflammatory drugs and acetaminophen on postpartum hypertension in patients with preeclampsia

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210823052269N1
Enrollment
110
Registered
2021-12-01
Start date
2021-11-06
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postpartum hypertension. Eclampsia in the puerperium

Interventions

Intervention 1: Intervention group 1: Mothers receiving acetaminophen 325 milligram suppository(Darupakhsh company) 24 hours after cesarean section every 6 hours until the end of hospitalization. Inte

Sponsors

Arak University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to 35 Years

Inclusion criteria

Inclusion criteria: Cesarean candidate patients No chronic liver, kidney, hemorrhagic disorders No history of allergy to nonsteroidal anti-inflammatory drugs and acetaminophen Severe preeclampsia or preeclampsia added to chronic hypertension with severe symptoms

Exclusion criteria

Exclusion criteria: Increase in liver enzyme levels higher than 200 mg / dL Increase in serum creatinine higher than 2 mg / dL

Design outcomes

Primary

MeasureTime frame
Primary variable: Duration of high blood pressure. Timepoint: Measure blood pressure for 24 hours every hour and then every 4 hours. Method of measurement: Mercury sphygmomanometer.;Primary variable: Frequency of need to use short acting antihypertensive drugs. Timepoint: Measure blood pressure for 24 hours every hour and then every 4 hours. Method of measurement: Counting.

Secondary

MeasureTime frame
Frequency of need to use short-acting antihypertensive drugs to control sudden hypertension in both groups receiving acetaminophen and nonsteroidal anti-inflammatory drugs. Timepoint: At the beginning of the study (before the intervention), for 24 hours every hour and then every 4 hours. Method of measurement: Counting.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMahsa Dargahian

Arak University of Medical Sciences

mooniaclinic@gmail.com+98 86 3313 6055

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026