melasma. Chloasma
Conditions
Interventions
Intervention 1: Intervention group: Group A will be given 30% topical metformin at night. Intervention 2: Intervention group: Group B will be given Triple Combination Cream (0.05% tretinoin, 2% hydroq
Sponsors
Combined Military Hospital, Quetta
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: Fitzpatrick skin types III- V No other melasma treatments in the last 6 weeks
Exclusion criteria
Exclusion criteria: Use of systemic photosensitizing drugs like phenytoin, tetracycline etc Pregnant or breastfeeding women Liver disease/ renal disease History of recent laser treatment or hypersensitivity to metformin or TCC.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in MASI scores from baseline. Timepoint: before intervention, 4week, 8 week, 12 week. Method of measurement: clinical examination and recording MASI score.;Incidence and severity of side effects (e.g., erythema, peeling, irritation, pigmentation). Timepoint: 4 weeks, 8 weeks, 12 weeks. Method of measurement: History and examination. | — |
Secondary
| Measure | Time frame |
|---|---|
| Quality of Life. Timepoint: Baseline, 4 week, 8 weeks, 12 weeks. Method of measurement: Melasma Quality of life score (MelasQoL).;Patient Satisfaction. Timepoint: 4 weeks, 8 weeks, 12 weeks. Method of measurement: Subjective improvement giving scores from 1 to 4 ( none, mild, moderate, marked improvement).;Recurrence. Timepoint: 16th week. Method of measurement: clinical examination. | — |
Countries
Pakistan
Contacts
Public ContactSAIMA ALI KHAN
Combined Military Hospital, Quetta
Outcome results
None listed