Skip to content

Comparison of efficacy of intramuscular meglumine antimoniate plus oral allopurinol with intramuscular meglumine antimoniate alone in treatment of cutaneous leishmaniasis

Comparison of efficacy of intramuscular meglumine antimoniate plus oral allopurinol with intramuscular meglumine antimoniate alone in treatment of cutaneous leishmaniasis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210823052264N6
Enrollment
150
Registered
2024-05-23
Start date
2024-05-10
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cutaneous leishmaniasis. Cutaneous leishmaniasis

Interventions

Intervention 1: Intervention group A: Patients were given drug via Intramuscular route injection meglumine antimoniate 15mg/kg if dose exceeds 10ml then it should be divided into two doses given on ea

Sponsors

CMH Quetta
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 55 Years

Inclusion criteria

Inclusion criteria: All patients with biopsy proven leishmaniasis or has lesion(s) located in sites not compatible with local treatment for example lesions on or around eyes Disfiguring lesion on face that lead to scarring Lesions difficult to heal like on lower limbs Lesion more than 4cm in size with sporotichoid spread Multiple lesions

Exclusion criteria

Exclusion criteria: patients allergic to antimonials Pregnant and breast feeding patients Patients having mucosal, mucocutaneous or visceral leishmaniasis Patients with comorbids (diabetes, hypertension, chronic liver disease, chronic kidney disease) Immunosuppression patients Baseline ECG abnormalities/heart disease

Design outcomes

Primary

MeasureTime frame
Healing of lesion in response to treatment. Timepoint: before intervention and 2, 4 , 6 and 8 weeks after intervention until complete healing occurs then patient called for followup after 4 weeks. Method of measurement: Clinical response.

Countries

Pakistan

Contacts

Public ContactDr Zainab Kazam

CMH Quetta

zainokazam@gmail.com+92 336 5534909

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026