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Comparison of Efficacy of Intravenous Versus Intramuscular Injection Meglumine Antimoniate in patients of Cutaneous Leishmaniasis

Comparison of Efficacy of Intravenous Versus Intramuscular Injection Meglumine Antimoniate in patients of Cutaneous Leishmaniasis

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210823052264N4
Enrollment
90
Registered
2024-04-03
Start date
2024-04-01
Completion date
Unknown
Last updated
2024-05-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cutaneous leishmaniaisis. Cutaneous leishmaniasis

Interventions

Intervention 1: Intervention group A: Patients were given drug via Intravenous route. The drug should be given diluted in 50–200 ml of 5% glucose solution over 30–60 minutes in ICU/HDU with cardiac mo

Sponsors

CMH Quetta
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 80 Years

Inclusion criteria

Inclusion criteria: All patients with biopsy proven leishmaniasis plus any of the following: has lesion(s) located in sites not compatible with local treatment for example eyelids lesions in which scaring would be disabling or severely disfiguring like on face lesions that will have difficulting in healing like on lower limb or over a joint lesions involving mucosa or cartilage lesion =4 cm lesion with sporotrichoid spread multiple lesions

Exclusion criteria

Exclusion criteria: patients allergic to antimonials the lesion is already self-curing pregnant and breast feeding women those who refused to accept the diagnostic procedures patients having mucosal, mucocutaneous or visceral leishmaniasis Patients with comorbidity (diabetes, hypertension,chronic liver disease,chronic kidney disease) and/or immunosuppression Patients with baseline ECG abnormalities/Heart disease

Design outcomes

Primary

MeasureTime frame
Healing of lesion in response to treatment. Timepoint: before intervention and 2, 4 , 6 and 8 weeks after intervention until complete healing occur than patient called for followup after 4 weeks. Method of measurement: Clinical Response Evaluation.

Countries

Pakistan

Contacts

Public ContactDr. Shafia Shaikh

CMH Quetta

shafiashaikh994@gmail.com+92 324 4153402

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026