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Efficacy of Oral Tofacitinib and Oral Prednisolone in moderate to severe Alopecia Areata - A comparative study

Efficacy of Oral Tofacitinib and Oral Prednisolone in moderate to severe Alopecia Areata - A comparative study

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210823052264N12
Enrollment
140
Registered
2024-12-19
Start date
2024-12-13
Completion date
Unknown
Last updated
2025-01-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Alopecia Areata. Alopecia areata

Interventions

Intervention 1: Intervention group: Group A will be given Tofacitinib 5 mg (twice daily) for three months. Intervention 2: Intervention group: Group B Patients will receive oral prednisolone 0.5 mg/Kg

Sponsors

Combined Military Hospital, Quetta, Pakistan
Lead Sponsor

Eligibility

Sex/Gender
All
Age
15 Years to 59 Years

Inclusion criteria

Inclusion criteria: Clinical diagnosis of alopecia areata with SALT score of 25 % or more Age Range 15-59 years Patients who have not taken oral, topical or systemic treatment for alopecia areata within 3 months prior to study

Exclusion criteria

Exclusion criteria: History of severe systemic diseases (Hepatic, renal, pulmonary and cardiovascular) Pregnant or nursing mother Those with other causes of hair loss; androgenetic alopecia, telogen effluvium, trichotillomania and cicatricial alopecia Hypersensitivity to medications Patients who are immunodeficient or undergoing immunosuppressive therapy

Design outcomes

Primary

MeasureTime frame
Change in SALT score from baseline. Timepoint: Before intervention, 2, 6,10 and 12th week. Method of measurement: Clinical Examination and recording SALT score.

Countries

Pakistan

Contacts

Public ContactRABBIA TARIQ

Combined Military Hospital, Quetta, Pakistan

rabbiaadil15@gmail.com+92 335 0244445

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026