Heart Failure. Systolic (congestive) heart failure
Conditions
Interventions
Intervention group: Women with left breast cancer who are treated with conventional 3D or hypofractionated radiation therapy with a dose of 50 Gy in 25 fractions or 42.5 Gy in 16 fractions..
Sponsors
Esfahan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: All patients with left breast cancer over the age of 18 that have undergone left breast radiation therapy at Omid Hospital Have not received chemotherapy or just received the TC (taxane-cyclophosphamide) chemotherapy regimen
Exclusion criteria
Exclusion criteria: Patients under 18 years old Patients with end stage or metastatic malignancy Patients with two synchronous cancers Patients with a history of heart failure with LVEF=50% or a history of valvular heart disease or advanced congenital heart disease or proven coronary artery disease Patients with a history of chest radiation therapy Pregnant patients with breast cancer Patients receives or have received of anthracyclines and trastuzumab
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heart mean dose in radiation therapy for left breast cancer. Timepoint: Before and 6 months after left breast radiotherapy. Method of measurement: Dose volume histogram. | — |
Secondary
| Measure | Time frame |
|---|---|
| Troponin. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Laboratory test.;Brain natriuretic peptide. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Laboratory test.;Left ventricle ejection fraction. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Echocardiography.;Global longitudinal strain. Timepoint: Before and just after left breast radiotherapy. Method of measurement: Echocardiography. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactAli Akhavan
Esfahan University of Medical Sciences
Outcome results
None listed