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The effect of Donepezil on memory impairment after Covid-19

Evaluation of the effect of Donepezil Hydrochloride on memory impairment in patients recovered from Covid-19 with hospitalization history in comparison with the control group

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210816052203N1
Enrollment
70
Registered
2021-08-24
Start date
2021-09-01
Completion date
Unknown
Last updated
2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Memory impairment due to Post acute COVID-19 syndrome (LONG-Covid Syndrome). SARS-associated coronavirus as the cause of diseases classified elsewhere

Interventions

Intervention 1: Intervention group: This group is treated with Donepezil Hydrochloride with the brand name Aricept at a dose of 5 mg (half a tablet for the first 5 nights and then one tablet overnight

Sponsors

Artesh University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All
Age
20 Years to 50 Years

Inclusion criteria

Inclusion criteria: Patients with the age between 20- 50 years old Memory impairment after recovery from Covid-19 Volunteer to participate in the study

Exclusion criteria

Exclusion criteria: History of previous cognitive problems History of CVA, head trauma or Cerebral hemorrhage History of underlying physical illnesses affecting cognitive function such as cancer, thyroid disorders, physical disorders with features of cognitive impairment such as Alzheimer's or any type of degenerative neurological disorder such as Parkinson's History of underlying mental illnesses such as major depression, anxiety disorders and psychotic disorders Use of drugs that affect cognitive function such as antidepressants, benzodiazepines, and anticonvulsants such as phenobarbital Drug, stimulant and alcohol using

Design outcomes

Primary

MeasureTime frame
Score of Wechsler Memory Scale Test. Timepoint: Measurement of memory indices at the beginning of the study (before intervention), one month later, three months later and six months after the intervention. Method of measurement: The Wechsler Memory Scale.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactMehdi Sakhabakhsh

Artesh University of Medical Sciences

drsakha2013@gmail.com+98 21 7750 7512

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 9, 2026