Assessment of the Effect of Pulmonary Rehabilitation in Patients with Chronic Obstructive Pulmonary Disease

Evaluation of Blood Inflammatory Markers and Their Comparison with Exercise Capacity Indices in Patients with Chronic Obstructive Pulmonary Disease Following Short-Term Pulmonary Rehabilitation

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210813052172N4

Enrollment

206

Registered

2026-05-05

Start date

2026-06-22

Completion date

Unknown

Last updated

2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic obstructive pulmonary disease. Chronic obstructive pulmonary disease, unspecified

Interventions

Intervention 1: Intervention group: In addition to active care, patients receive education on care techniques and bedside physiotherapy, undergo a full rehabilitation program, and participate in a str

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: Definitive diagnosis of COPD based on GOLD criteria Age over 18 years Stability of the patient’s clinical condition at the time of study entry Ability to perform functional tests

Exclusion criteria

Exclusion criteria: Exacerbation of the disease within the past two weeks Acute respiratory symptoms or infection during pulmonary rehabilitation period Incomplete training sessions for any reason Lack of willingness to cooperate in performing functional tests or completing questionnaires

Design outcomes

Primary

Measure	Time frame
Neutrophil-to-lymphocyte ratio. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Complete Blood Count.;Platelet-to-lymphocyte ratio. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Complete Blood Count.;Erythrocyte sedimentation. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Complete Blood Count.	—

Measure

Time frame

Neutrophil-to-lymphocyte ratio. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Complete Blood Count.;Platelet-to-lymphocyte ratio. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Complete Blood Count.;Erythrocyte sedimentation. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Complete Blood Count.

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Secondary

Measure	Time frame
Exercise capacity. Timepoint: Before initiation pulmonary rehabilitation and after 10 days pulmonary rehabilitation. Method of measurement: Six minute walk test.;Strength and endurance of the lower limb muscles. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Sit to stand test.;Dyspnea. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Borg scale questionnaire.;Fatigue. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Borg scale questionnaire.;Quality of life. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: St. George's Questionnaires and Chronic Obstructive Pulmonary Disease Assessment Test (CAT).	—

Measure

Time frame

Exercise capacity. Timepoint: Before initiation pulmonary rehabilitation and after 10 days pulmonary rehabilitation. Method of measurement: Six minute walk test.;Strength and endurance of the lower limb muscles. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Sit to stand test.;Dyspnea. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Borg scale questionnaire.;Fatigue. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: Borg scale questionnaire.;Quality of life. Timepoint: Before starting pulmonary rehabilitation and after completing 10 days of pulmonary rehabilitation. Method of measurement: St. George's Questionnaires and Chronic Obstructive Pulmonary Disease Assessment Test (CAT).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactMaryam Sadat Mirenayat

Shahid Beheshti University of Medical Sciences

MirenayaT_M@yahoo.com+98 21 2612 5050

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Jun 11, 2026