Evaluation of the effects of Streptococcus salivarius M18 and K12 probiotic bacteria on the amount of Streptococcus mutans in saliva: a randomized clinical trial

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210811052147N1

Enrollment

Registered

2021-10-17

Start date

2021-10-20

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Dental caries. Dental caries

Interventions

Intervention 1: Intervention group: to standardize oral hygiene, both intervention and control groups are given brushing training one week before the intervention. People also use a type of toothpaste

Eligibility

Sex/Gender

All

Age

19 Years to 35 Years

Inclusion criteria

Inclusion criteria: People without orthodontics or people who have had orthodontic treatment for more than six months People who have not taken antibiotics in the past month People who do not have incomplete dental treatment People without immune system diseases

Exclusion criteria

Exclusion criteria: People with orthodontic appliques or people who have had orthodontic treatment for less than six months People who have taken antibiotics in the past month People undergoing incomplete dental treatment People with immune system diseases

Design outcomes

Primary

Measure	Time frame
The amount of Streptococcus mutans in saliva. Timepoint: Saliva samples are collected at the beginning and end of the intervention. Method of measurement: Bacteria are measured based on colony count.	—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFiroozeh Nilchian

Esfahan University of Medical Sciences

f_nilchian@dnt.mui.ac.ir+98 31 3792 5594

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026