Evaluation of probiotic supplementation effect on anxiety, inflammatory factors and oxidative stress biomarkers in patients undergoing third molar surgery

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210811052144N1

Enrollment

Registered

2022-01-24

Start date

2022-01-10

Completion date

Unknown

Last updated

2022-02-07

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anxiety caused by wisdom tooth surgery.

Interventions

Intervention 1: Intervention group: Recipient of bioflora probiotic - product of takgene company - contains Lactobacillus acidophilus, Bifidobacterium ? Bifidum, Bifidobacterium Lactis and Bifidobacte

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Inclusion criteria

Inclusion criteria: patients having impacted third molar

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
NO. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;Total Glutathione. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;High-sensitivity C-reactive protein. Timepoint: Beginning and end of the intervention. Method of measurement: ELISA kit.	—

Measure

Time frame

NO. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;Malondialdehyde. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;Total antioxidant capacity. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;Total Glutathione. Timepoint: Beginning and end of the intervention. Method of measurement: Spectrophotometry.;High-sensitivity C-reactive protein. Timepoint: Beginning and end of the intervention. Method of measurement: ELISA kit.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactVahid Kiani

Kashan University of Medical Sciences

vahidkiyani448@yahoo.com+98 31 5325 3156

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026