cancer of cervix. Malignant neoplasm of cervix uteri
Conditions
Interventions
Intervention group:Recieving 4 course chemotherapy with carboplatin (Area under curve
AUC:5)and paclitaxel (175mg per square meter)every three week before chemoradiation with External beam radiation and brachytherapy up to 80 to 90Gy to high risk Clinical target volume (CTV)with prescr
Sponsors
Shiraz University of Medical Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Unresectable cervical cancer(IIB toIVA,IB3,IIAmore than 4cm) 2.No history of metastasis 3.Adequate renal function(GFR more than 60ml per min per1.73) 4.Adequate hepatic function(Liver enzyme1500) 6-Without history of systemic disease 7.Absence of active infection 8.Absence of previous or concurrent oncology pathology 9.ECOG performance status 0 and 1 10.Age 18 to 75 years
Exclusion criteria
Exclusion criteria: 1-Previous pelvic radiation 2-Pregnancy 3-Serious medical illness 4-Hypersensitivity to chemotherapy agent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Response to treatment 3 months after fulfilling it. Timepoint: 3 months after fulfilling treatment. Method of measurement: To do MRI and evaluate response to treatment by recist 1.1 guideline. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactMarzieh Heidarpourfard
Shiraz University of Medical Sciences
Outcome results
None listed