Effects of naproxen, diclofenac and piroxicam on Mandibular joint pain

Comparison of the effects of Naproxen, Diclofenac and Piroxicam on TMD

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210807052101N1

Enrollment

104

Registered

2021-10-04

Start date

2015-08-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Temporo Mandibular Disorders. Temporomandibular joint disorders

Interventions

Intervention 1: The first Intervention group take Naproxen tablet 500 mg (Chemidarou, Tehran, Iran) twice a day for 10. Intervention 2: The second Intervention group: Diclofenac tablet 50 mg (Shahreda

Eligibility

Sex/Gender

All

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Pain in masticatory muscles Limitation in mouth opening Clicking sound TMJ touch sensivity No systemic disease No previous supportive treatments

Exclusion criteria

Exclusion criteria: Existence of systemic disease Receive previous supportive treatments

Design outcomes

Primary

Measure	Time frame
Pain. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of pain was measured with VAS index (visual analog scale).;The amount of clicking. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of clicking sound was measured with stethoscope.;The amount of tenderness. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The degree of sensitivity to touch were done by touching the masticatory muscles and the joint area.;The amount of opening mouth. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of mouth opening was measured with a cloth ruler (the distance between the upper and lower incisors at the maximum amount of mouth opening).	—

Measure

Time frame

Pain. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of pain was measured with VAS index (visual analog scale).;The amount of clicking. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of clicking sound was measured with stethoscope.;The amount of tenderness. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The degree of sensitivity to touch were done by touching the masticatory muscles and the joint area.;The amount of opening mouth. Timepoint: Time table for evaluation patients includes; the first assessment before starting treatment, the second assessment one week after starting treatment, the third session three weeks after therapy, the fourth evaluation five weeks after treatment and the fifth session six weeks after therapy. Method of measurement: The amount of mouth opening was measured with a cloth ruler (the distance between the upper and lower incisors at the maximum amount of mouth opening).

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactAli Peimani

Rafsanjan University of Medical Sciences

alipeimani2001@yahoo.com+98 34 3428 0038

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026