Evaluation of the effect of vitamin D consumption on the AntiTPO

The effect of vitamin D intake on AntiTPO levels in hypothyroid and euthyroid patients with anti-TPO positive: an interventional study

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210802052054N1

Enrollment

128

Registered

2022-05-14

Start date

2022-05-14

Completion date

Unknown

Last updated

2022-05-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Autoimmune Hypothyroidism. Autoimmune thyroiditis

Interventions

Intervention 1: Intervention group: Patients who are Anti-TPO positive and have elevated TSH and are deficient in vitamin D whose serum level of vitamin D is less than 10ng /ml . For 8 weeks, 50,000 u

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients of both sexes who have AntiTPO positive and their disease is approved by an endocrinologist and are in the age range of 18 to 65 years.

Exclusion criteria

Exclusion criteria: Patients who have evidence of any disease that affects the balance of the immune system, such as those with type 1 diabetes, multiple sclerosis, inflammatory bowel disease, and other autoimmune diseases. Patients with impaired liver enzyme function Malnourished patients Patients with a BMI of less than 18 or more than 40. Patients with hyperthyroidism and decreased TSH levels.

Design outcomes

Primary

Measure	Time frame
Serum levels of Anti TPO before and after taking vitamin D. Timepoint: Anti TPO levels are measured before the intervention and 3 and 6 months after the start of vitamin D intake. Method of measurement: After starting the study, blood samples are taken from the patients and the patients' serum is removed. Using special Anti TPO kits, the level of Anti TPO is measured by ELISA and the effect of vitamin D level on the level of Anti TPO in the serum is examined.	—

Measure

Time frame

Serum levels of Anti TPO before and after taking vitamin D. Timepoint: Anti TPO levels are measured before the intervention and 3 and 6 months after the start of vitamin D intake. Method of measurement: After starting the study, blood samples are taken from the patients and the patients' serum is removed. Using special Anti TPO kits, the level of Anti TPO is measured by ELISA and the effect of vitamin D level on the level of Anti TPO in the serum is examined.

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Secondary

Measure	Time frame
Evaluation of serum vitamin D levels in patients with Anti TPO positive. Timepoint: Serum vitamin D levels are measured before the intervention and 3 and 6 months after the start of vitamin D intake. Method of measurement: After starting the study, blood samples are taken from the patients and the patients' serum is removed. Using special Vitamin D kits, the level of vitamin D is measured by ELISA.	—

Measure

Time frame

Evaluation of serum vitamin D levels in patients with Anti TPO positive. Timepoint: Serum vitamin D levels are measured before the intervention and 3 and 6 months after the start of vitamin D intake. Method of measurement: After starting the study, blood samples are taken from the patients and the patients' serum is removed. Using special Vitamin D kits, the level of vitamin D is measured by ELISA.

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Countries

Iran (Islamic Republic of)

Contacts

Public ContactSima Shahmohammadi Farid

Tabriz University of Medical Sciences

shahmohammadis@tbzmed.ac.ir+98 41 1334 3010

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026