Evaluation of the effect of bromelain on pain after root canal treatment

Evaluation of the effects of bromelain and acetaminophen in reduce postoperative pain following root canal therapy with symptomatic irreversible pulpitis in comparision with placebo and acetaminophen

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210802052051N1

Enrollment

Registered

2021-08-29

Start date

2021-09-04

Completion date

Unknown

Last updated

2021-08-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Pain after root canal therapy. Pulpitis

Interventions

Intervention 1: Control group:Half of the samples receiving acetaminophen 500 mg and placebo every 6 hours until the pain improved and their pain before treatment, 24, 12, 6 and 48 hours after treatme

Eligibility

Sex/Gender

All

Age

10 Years to No maximum

Inclusion criteria

Inclusion criteria: The age range of all patients be 10 years and older tooth Periapical tissue be normal

Exclusion criteria

Exclusion criteria: Pregnant women do not enter the study Patients who have kidney and coagulation problems Patients taking anticoagulants patient has a systemic problem

Design outcomes

Primary

Measure	Time frame
Pain Score in Visual Analog Scale System (VAS). Timepoint: Before treatment and 6,12,24and 48hours after treatment. Method of measurement: Visual analog scale.	—

Secondary

Measure	Time frame
Evaluation of the effecacy of bromelaine in reduce postoperative pain following root canal therapy secondary consequences can be a pain reduction score. Timepoint: To measure pain befor root canal therapy , 6 ,12 ,24 and 48 hours after root canal therapy is used . Method of measurement: Evaluation of the effecacy of bromelaine in reduce postoperative pain following root canal therapy secondary consequences pain reduction score Visual Analogue Scale can be used .	—

Measure

Time frame

Evaluation of the effecacy of bromelaine in reduce postoperative pain following root canal therapy secondary consequences can be a pain reduction score. Timepoint: To measure pain befor root canal therapy , 6 ,12 ,24 and 48 hours after root canal therapy is used . Method of measurement: Evaluation of the effecacy of bromelaine in reduce postoperative pain following root canal therapy secondary consequences pain reduction score Visual Analogue Scale can be used .

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactFatemeh Abbasi

Esfahan University of Medical Sciences

f.abbasi@dnt.mui.ac.ir+98 31 3792 5514

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026