Chronic Obstructive Pulmonary Disease. Chronic obstructive pulmonary disease with (acute) exacerbation
Conditions
Interventions
Intervention 1: Intervention group: In the intervention group, patients with severe COPD who require NIV will receive standard treatments including bronchodilators, systemic corticosteroids (prednisol
Sponsors
Hamedan University of Medical Sciences
Eligibility
Sex/Gender
All
Age
30 Years to 80 Years
Inclusion criteria
Inclusion criteria: age between 30 and 80 years , patients with COPD experiencing an exacerbation (defined as having at least two of the three following criteria: increased dyspnea, increased sputum volume, and a change in sputum color to purulent sputum), need for NIV providing written informed consent to participate in the study
Exclusion criteria
Exclusion criteria: • Need for mechanical ventilation at the time of admission • History of cerebrovascular disease • History of myocardial infarction and stroke
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in blood pH. Timepoint: Before treatment - 3 days after treatment - 5 days after treatment. Method of measurement: Arterial blood sampling and gas analyzer device.;PCO2. Timepoint: Before treatment - 3 days after treatment - 5 days after treatment. Method of measurement: Arterial blood sampling and gas analyzer device.;O2 saturation. Timepoint: Before treatment - 3 days after treatment - 5 days after treatment. Method of measurement: Pulse oximeter. | — |
Secondary
| Measure | Time frame |
|---|---|
| Severity of dyspnea. Timepoint: Before treatment - 3 days after treatment - 5 days after treatment. Method of measurement: With the BORG scale.;Duration of need for NIV. Timepoint: Throughout the patient’s hospital stay. Method of measurement: Duration of NIV use for each patient.;Duration of hospital stay. Timepoint: Throughout the patient’s hospital stay. Method of measurement: Duration of stay for each patient.;Intubation. Timepoint: Throughout the patient’s hospital stay. Method of measurement: Patient’s clinical status and treatment decisions.;Admission to ICU. Timepoint: Throughout the patient’s hospital stay. Method of measurement: Patient’s clinical status and treatment decisions. | — |
Countries
Iran (Islamic Republic of)
Contacts
Public ContactZohreh Kahramfar
Hamedan University of Medical Sciences
Outcome results
None listed