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Evaluation of the efficacy of oral N- acetylcysteine in the treatment of vitiligo patients

Evaluation of the efficacy of NB-UVB phototherapy with oral N- acetylcysteine compared with NB-UVB phototherapy alone in the treatment of vitiligo patients: a randomized controlled clinical trial

Status
Recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210729052013N1
Enrollment
40
Registered
2021-12-04
Start date
2021-12-11
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vitiligo disease. Vitiligo

Interventions

Intervention 1: intervention group: Participants in the intervention group are treated with Dr Honle Drmalight 3000 phototherapy device with a wavelength of 311 nm 3 times a week for four months. The

Sponsors

Iran University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: People with generalized vitiligo who volunteer for NB-UVB phototherapy

Exclusion criteria

Exclusion criteria: Patients with focal or segmental vitiligo Patients with other skin diseases Patients with a history of gastrointestinal ulcers Patients with photosensitivity Patients who have received systemic or topical medication for 2 months Pregnant and lactating women

Design outcomes

Primary

MeasureTime frame
Vitiligo severity score. Timepoint: At the beginning of the study (before the intervention), 2 and 4 months after the start of treatment. Method of measurement: Vitiligo Extent Tensity Index (VETI) score, which its maximum value is 55.5.

Secondary

MeasureTime frame
The patient's tolerance of the treatment. Timepoint: Measurement periods: 2 and 4 months after starting treatment. Method of measurement: At each visit, patients determine their tolerance by choosing one of the following options: 1. Yes 2. No.;The patient's satisfaction with the treatment. Timepoint: Measurement periods: 2 and 4 months after starting treatment. Method of measurement: At each visit, patients determine their level of satisfaction by choosing one of the following options: 1. No 2. A little 3. Moderate 4. Good 5. Excellent.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactSaeideh Farahani

Iran University of Medical Sciences

farahani.104@gmail.com+98 21 2262 3759

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026