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Comparison of Efficacy Permethrin topical Cream in Combination with Doxycycline Tablet with Ivermectin topical Cream in Combination with Doxycycline Tablet in Treatment of cutaneus disease Rosacea Patients

Comparison of Efficacy Permethrin 5% Cream with Ivermectin 1% Cream in Combination with Oral Doxycycline in Treatment of Papulopustular Rosacea Patients

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210729052010N1
Enrollment
40
Registered
2021-12-24
Start date
2022-01-21
Completion date
Unknown
Last updated
2022-01-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rosacea papulopustular disease.

Interventions

Intervention 1: First Intervention group:use of permethrin 5% topical cream produced by Gilan daroo company for 12 weeks on cutaneus lesions for 20 papulopustular rosacea patients and photography from

Sponsors

Esfahan University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
Female
Age
18 Years to No maximum

Inclusion criteria

Inclusion criteria: Diagnosis of typical papulopustular rosacea according two dermatologists and performance biopsy if rosacea is suspected No treatment with topical steroids or other topical treatment during 14 days before starting study No treatment with any systemic drugs by known effect on inflammation responses during 30 days before starting study No treatment with topical retinoids during 30 days ago or systemic retinoids during 180 days before starting study No treatment by physical modality that effect on rosacea lesions during 30 days before starting study Absence of other cutaneous diseases that interfere with assessment lesions related to rosacea Absence of comedon, cyst and scar that benefit to diagnosis of acne vulgaris Absence of pregnancy and breastfeeding

Exclusion criteria

Exclusion criteria: Less than 18 years Male gender

Design outcomes

Primary

MeasureTime frame
Increase or decrease number and severity after use Ivermectin 1% cream or permetrin 5% cream. Timepoint: 0,6 and 12 weeks after starting treatment. Method of measurement: Photography from lesions and remission of lesions.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactNazila Poostiyan

Esfahan University of Medical Sciences

Alzahra@mui.ac.ir+98 31 3620 2020

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026