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A comparison between ketamine and precedex in treatment of shivering

A comparison between intravenous ketamine and precedex (dexmedetomidine) in treatment of postoperative shivering after nose surgeries

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
IRCT
Registry ID
IRCT20210728052003N1
Enrollment
88
Registered
2021-09-08
Start date
2020-03-20
Completion date
Unknown
Last updated
2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

postoperative shivering. Other ossification of muscle, unspecified site

Interventions

Intervention 1: Intervention group: Ketamine group: They receives 0.3 mg / kg / IV treatment of ketamine. Intervention 2: Intervention group: Percedex receiving group: They receive 1 µg / kg / IV trea

Sponsors

Sanandaj University of Medical Sciences
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: Patients undergoing elective nasal surgery with a duration of 1-2 hours (including rhinoplasty, septoplasty, functional endoscopic sinus surgery, polyps, and other intranasal masses) Patients receiving general anesthesia Patients with shivering after surgery Patients with ASA class one and two

Exclusion criteria

Exclusion criteria: Patients with ASA class three and more Patients with a history of tremor and Parkinson's disease Patients with a history of thyroid, heart, kidney, and liver diseases, anemia (hemoglobin less than 9) Patients with a history of allergies Patients receiving blood during surgery Patients with a history of neurology and psychology diseases Patients with a history of myopathy Drug users

Design outcomes

Primary

MeasureTime frame
The primary or main outcome of this study is faster treatment of shivering in patients with shivering after anesthesia. (Reduce patients' chills). Timepoint: The degree of shivering in patients is determined and recorded before receiving the drug and from zero to 10 minutes every minute after receiving the drug. Method of measurement: Postoperative shivering grading: Based on 5-digit grading (0 to 4) Grade 0: No shivering. Grade 1: Mild cold and chills on face or neck or one or more of the symptoms: Mild peripheral vasoconstriction, peripheral cyanosis, body hair spiking for no other reason. Grade 2: Moderate chills (involvement of one muscle group: oral muscle spasm) Grade 3: Severe chills (involvement of more than one muscle group without generalized involvement: spasm of all facial muscles) Grade 4: Generalized body chills.

Secondary

MeasureTime frame
Body temperatures. Timepoint: Patients' body temperature is recorded 5 times before induction of anesthesia, at the time of entering the recovery, before receiving the drug, 5 minutes after receiving the drug and 10 minutes after receiving the drug. Method of measurement: It is measured from the axillary area by a thermometer.;Hemodynamic changes. Timepoint: For both groups of patients, hemodynamic variables including HR, RR , SBP and DBP, SaO2 4 times before medication,1 minute after receiving the drug and 5 and 10 minutes after receiving the drug is recorded. Method of measurement: HR (via distal pulse of the upper limb), RR (number of patient breaths per minute), SBP and DBP (via barometer), SaO2 (via pulse oximetry).;Side effects from medications. Timepoint: Patients are monitored and recorded for drug side effects, including nausea and vomiting, tachycardia, hypertension, nystagmus, delirium, and other side effects up to 30 minutes after receiving the drug. Method of measurement: Patients are evaluated after receiving the drug.

Countries

Iran (Islamic Republic of)

Contacts

Public ContactBehzad Ahsan

Sanandaj University of Medical Sciences

behzad.ahsan@muk.ac.ir+98 87 3361 1232

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026