Comparison of with and without preoxygenation methods in patients needed procedural sedation and anesthesia

Comparison of with and without preoxygenation methods in patients needed procedural sedation and anesthesia with ketamine and propofol in Sina Hospital's emergency department

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

IRCT

Registry ID

IRCT20210724051964N1

Enrollment

126

Registered

2021-09-13

Start date

2021-08-23

Completion date

Unknown

Last updated

2021-11-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Preoxygenation in patients required sedation and anesthesia in ED.

Interventions

Intervention 1: Intervention group: Air prescription in patients required sedation and anesthesia. Intervention 2: Control group: Oxygen prescription in patients required anesthesia in ED.

Eligibility

Sex/Gender

All

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients needed procedural sedation and anesthesia in ED

Exclusion criteria

Exclusion criteria: Age 65 Pregnant patients History of ischemic heart disease and Congestive heart disease History of restrictive or obstructive lung disease Oxygen saturation less than 92% at rest Allergy history to egg Allergy history to Ketamine or Propofol Systolic blood pressure more than 180 or less than 90 mmhg before procedure Patients who did not tend to participate in the study Patients who are unable to sign consent

Design outcomes

Primary

Measure	Time frame
Decreased oxygen saturation, which includes the disappearance of the capnograph wave or the drop in oxygen saturation measured by the pulse oximeter. Timepoint: At the beginning, 10, 20 and 30 min after administration of oxygen or air. Method of measurement: Using capnography and pulse oximerty.	—

Secondary

Measure	Time frame
Decreasing in blood pressure more than 10% of patient's basic blood pressure. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Blood pressure cuff measurement of monitors.;Variation of end tidal Co2. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Capnograph.;Heart rate decreasing. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By monitor at the bedside.;Apnea occurrence. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Capnography and pulse oximetry.	—

Measure

Time frame

Decreasing in blood pressure more than 10% of patient's basic blood pressure. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Blood pressure cuff measurement of monitors.;Variation of end tidal Co2. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Capnograph.;Heart rate decreasing. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By monitor at the bedside.;Apnea occurrence. Timepoint: At the beginning , 10 , 20 and 30 minutes after prescription of oxygen or air. Method of measurement: By Capnography and pulse oximetry.

—

Countries

Iran (Islamic Republic of)

Contacts

Public ContactAlireza Jalali

Tehran University of Medical Sciences

ajalali@sina.tums.ac.ir+98 21 6312 1432

Outcome results

None listed

Source: IRCT (via WHO ICTRP) · Data processed: Feb 4, 2026